ABSTRACT
Drugs used in the management of pregnancy-induced hypertension have been reviewed, and their value and adverse effects on both mother and fetus have been considered. Although magnesium and hydralazine remain the stalwarts of therapy, a number of other drugs have potential that may be realized in the future. Several new medications have promise in correcting the derangements of toxemia, but safety for the fetus has yet to be demonstrated. For the physician confronted with the complexities of old and new drugs in toxemia of pregnancy, the prayer of Lord Berkely may be just as appropriate in 1977 as it was dicades ago: From inability to let well enough alone, From too much zeal for the new, From too much contempt for what is old, From putting knowledge before wisdom and science before art, From making the cure of the disease more grievous than its endurnace, Good Lord, deliver us.
Subject(s)
Anticonvulsants/therapeutic use , Antihypertensive Agents/therapeutic use , Diuretics/therapeutic use , Pre-Eclampsia/drug therapy , Barbiturates/adverse effects , Benzothiadiazines , Blood Volume , Diazepam/adverse effects , Diazepam/therapeutic use , Ethacrynic Acid/adverse effects , Female , Furosemide/adverse effects , Furosemide/therapeutic use , Heparin/adverse effects , Humans , Hydralazine/adverse effects , Hydralazine/therapeutic use , Magnesium/adverse effects , Magnesium/therapeutic use , Mannitol/adverse effects , Mannitol/therapeutic use , Methyldopa/therapeutic use , Myometrium/drug effects , Phytotherapy , Plants, Medicinal , Plants, Toxic , Pregnancy , Ritodrine/therapeutic use , Secologanin Tryptamine Alkaloids/therapeutic use , Sodium Chloride Symporter Inhibitors/adverse effects , Sodium Chloride Symporter Inhibitors/therapeutic use , Veratrum/therapeutic useSubject(s)
Plants, Medicinal , Plants, Toxic , Veratrum , Animals , Chemical Phenomena , Chemistry , Chromatography, Thin Layer , Diaphragm , Hydrolysis , In Vitro Techniques , Myasthenia Gravis/drug therapy , Phytotherapy , Rats , Spectrophotometry, Ultraviolet , Veratrum/analysis , Veratrum/therapeutic useSubject(s)
Myasthenia Gravis/drug therapy , Phytotherapy , Plants, Medicinal , Plants, Toxic , Veratrum/administration & dosage , Acetates/administration & dosage , Acetates/adverse effects , Acetates/therapeutic use , Administration, Oral , Adolescent , Adult , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , Veratrum/adverse effects , Veratrum/therapeutic useSubject(s)
Myasthenia Gravis/drug therapy , Acetates/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Adrenocorticotropic Hormone/administration & dosage , Adrenocorticotropic Hormone/therapeutic use , Ambenonium Chloride/therapeutic use , Aminophylline/therapeutic use , Anesthetics, Local/therapeutic use , Anti-Arrhythmia Agents/therapeutic use , Anti-Bacterial Agents/therapeutic use , Atropine/therapeutic use , Bromides , Choline/therapeutic use , Cholinesterase Inhibitors/administration & dosage , Cholinesterase Inhibitors/pharmacology , Cholinesterase Inhibitors/therapeutic use , Edrophonium/therapeutic use , Hospitals, Special , Humans , Myasthenia Gravis/physiopathology , Myasthenia Gravis/therapy , Neostigmine/therapeutic use , Physostigmine/therapeutic use , Phytotherapy , Plants, Medicinal , Plants, Toxic , Synaptic Transmission/drug effects , United States , Veratrum/therapeutic useSubject(s)
Botulism/drug therapy , Guanidines/therapeutic use , Phytotherapy , Plants, Medicinal , Plants, Toxic , Veratrum/therapeutic use , Action Potentials/drug effects , Animals , Botulinum Toxins/pharmacology , Botulism/chemically induced , Drug Combinations , Evoked Potentials/drug effects , Female , Muscles/drug effects , RabbitsSubject(s)
Hypertension/drug therapy , Adrenergic beta-Antagonists/adverse effects , Adrenergic beta-Antagonists/pharmacology , Adrenergic beta-Antagonists/therapeutic use , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/adverse effects , Antihypertensive Agents/therapeutic use , Benzyl Compounds/therapeutic use , Clonidine/pharmacology , Clonidine/therapeutic use , Diazoxide/adverse effects , Diazoxide/pharmacology , Diazoxide/therapeutic use , Ganglionic Blockers/adverse effects , Ganglionic Blockers/therapeutic use , Guanethidine/adverse effects , Guanethidine/pharmacology , Guanethidine/therapeutic use , Guanidines/therapeutic use , Humans , Monoamine Oxidase Inhibitors/adverse effects , Monoamine Oxidase Inhibitors/pharmacology , Monoamine Oxidase Inhibitors/therapeutic use , Phytotherapy , Plants, Medicinal , Plants, Toxic , Veratrum/adverse effects , Veratrum/pharmacology , Veratrum/therapeutic useABSTRACT
PIP: A 65-year-old woman was admitted to the hospital because of dyspnea. 15 years previously biopsy of an enlarged left cervical lymph node revealed giant-follicle lymphoma; the patient received radiation. 7 years before a right radical mastectomy was performed for an adenocarcinoma of the breast; there were metastases to several anxillary lymph nodes. 4 years before, a malignant lymphoma was discovered again and radiation successfully given. 5 months before admission there was an onset of severe dyspnea. Upon admission, the temperature was 36.9 degrees C, pulse 100, and respirations 32. Blood pressure was 120/70. Oxygen, prednisone, furosemide, chlordiazepoxide, and morphine were administered. The woman died the 2nd day. Clinical diagnoses showed that the woman died of carcinoma of the breast with metastoses to mediastinal lymph nodes, the chest wall and the lungs, and that lymphoma was inactive. Radiation may have caused the late malignant tumor. A late radiation-induced complication may be another malignant tumor. It is noted that radiation therapy may be a calculated risk in some cases.^ieng